The authors review advances in developing durable immune tolerance. Bipolar disorder has a yearly prevalence of 2%. Mechanisms underlying these regulators are increasingly being elucidated, and agents that alter their function are being developed as treatments. The diagnosis of Covid-19 is usually based on SARS-CoV-2 PCR testing of a nasopharyngeal swab or other specimen. A common pathophysiological mechanism is autoimmunity. Cancer-cell biology is dictated by alterations in epigenetic regulation of gene expression. Reviewed are mechanisms and phenotypic features of plaque healing, its role in clinical events, and therapeutic implications. This review focuses on CAH due to 21-hydroxylase deficiency. Trigeminal neuralgia is manifested by severe, paroxysmal facial pain. Sensory ganglionopathy is characterized by sensory loss without weakness. Oral contraceptives lower the risk by 30 to 40%. Dysregulated autophagy is associated with certain cancers, neurodegenerative diseases, immune dysfunction, and aging. Trigeminal neuralgia is manifested by severe, paroxysmal facial pain. Early surgery is indicated in some patients. Concise summaries and expert physician commentary that busy clinicians need to enhance patient care. It is linked with obesity, excess estrogen, and the Lynch syndrome. Sodium-channel blockers are the first-choice treatment; if they are unsuccessful, vascular decompression or ablative procedures may be used. Stay connected to what's important in medical research and clinical practice, Subscribe to the most trusted and influential source ofmedical knowledge. Review ArticleNov 19, 2020 Endometrial Cancer Lu K.H. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. Prepare to become a physician, build your knowledge, lead a health care organization, and advance your career with NEJM Group information and services. Recommended treatments in selected patients include intravenous thrombolysis with alteplase and mechanical thrombectomy. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Amphetamines and methylphenidate and, less often, nonstimulants (atomoxetine, clonidine, and guanfacine) are used to treat ADHD. The content of this site is intended for health care professionals. Elaborate mechanisms control immune responses, but in some cases, the response either does not recognize the danger or causes unwanted autoinflammation. Valuable tools for building a rewarding career in health care. In many countries, a large majority of adults consume caffeine daily. This review summarizes the evidence about the varied physiological effects of caffeine and coffee and the risks of cardiovascular disease, insulin resistance, gallstones, cancer, and liver disease. … Oral contraceptives lower the risk by 30 to 40%. The biology, clinical presentation, and treatment of the more common disorders are discussed. In many countries, a large majority of adults consume caffeine daily. Esophageal motility disorders and esophageal reflux are common, produce a wide range of symptoms, and compromise quality of life. Improvements in diagnosis and treatment have improved the management of these disorders. Physical tests and imaging aid in determining the source of disability. Mechanisms underlying these regulators are increasingly being elucidated, and agents that alter their function are being developed as treatments. The trigeminal nerve and its projections to the intracranial vasculature — the trigeminovascular system — are at the nexus of migraine. | N Engl J Med 2020; 383:2053-2064 Endometrial carcinoma is diagnosed in about … The classical type involves compression of the trigeminal nerve root. Degeneration of the elements of the cervical spine, which is almost inevitable with age, results in nerve-root and spinal cord compression and pain. American Heart Association Scientific Sessions, From Portraits to Role Models — Why We Need Black Physicians in Academic Medicine, Solving Population-wide Obesity — Progress and Future Prospects, The Bottom of the Health Care Rationing Iceberg, A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19, Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve, Once-Weekly Insulin for Type 2 Diabetes without Previous Insulin Treatment, A Randomized Trial of Laryngeal Mask Airway in Neonatal Resuscitation. Prepare to become a physician, build your knowledge, lead a health care organization, and advance your career with NEJM Group information and services. This review focuses on acquired sensory ganglionopathies, most commonly seen in patients with an autoimmune disease or a paraneoplastic disorder. Concise summaries and expert physician commentary that busy clinicians need to enhance patient care. Please provide a 'From' date that is before the 'To' date. Although idiopathic pulmonary fibrosis is very common, the review focuses mainly on fibrotic diseases other than IPF. This review covers fibrotic pulmonary diseases. Sensory ganglionopathy is characterized by sensory loss without weakness. This review focuses on CAH due to 21-hydroxylase deficiency. Down syndrome is phenotypically variable, but programs have been introduced to capitalize on each person’s best abilities. Other mental and physical conditions occur with bipolar disorder, which is also associated with an increased risk of suicide. The authorized source of trusted medical research and education for the Chinese-language medical community. Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery. Inattentiveness and restlessness are improved more than quality-of-life measures in short-term trials. Explore a collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary. The diagnosis of infectious endocarditis is based on modified Duke criteria, according to findings on physical examination, echocardiography, microbiologic studies, and imaging of target organs. 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2020 nejm review articles